By Colin R. Howard, Howard
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Extra resources for Arenaviruses (Developments in Biochemistry)
The carriage rate in both species appeared to be about 3-1296. However, longitudinal studies of 18 30, 0 w k U 20. I M 10 ' I , , , . 64 65 66 67 , . . 68 69 70 71 YEAR Fig. 5. , 1977). Isolations are shown and Oryzomys (-) species. from Neaconzys (m) naturally infected animals showed that there was considerable oscillation in the level of circulating virus, with infectivity occasionally becoming undetectable in either blood or urine. Interestingly, the annual infection rate in both Oryzomys and Neacomys spp.
For example, Buchmeier et al. ( 1980b) characterized 46 monoclonal reagents raised against the Armstrong CA1371 strain of LCM virus. Cross-reactivity was detected with five antibodies by indirect immunofluorescence using cells infected with Lassa or Mopeia viruses and a sixth reacted with the Mopeia virus only. Interestingly, this reagent specific for LCM and Mopeia viruses only recognized the external G 2 glycoprotein (see Chapter 7) of LCM virus whereas the remaining antibodies additionally recognized Lassa-infected cell substrates were directed against epitopes on the internal nucleocapsid of the LCM virion.
Early studies designed to detect and quantitate neutralizing antibodies to LCM virus showed that this reactivity is thermolabile. For example, Ackermann et al. ( 1962) found significant decreases in log neutralization indices of positive human sera after heating for 20 min at 56°C. , 1959). An unexplained phenomenon was the finding by Ackermann et al. that thermal inactivation at elevated temperatures could be partially reversed by subsequent storage at room temperature or below. , 1960). In the absence of critical data outlining the development of IgM neutralizing antibodies, these studies showed the limitation of single samples for serodiagnosis using neutralizing antibody as the sole marker of infection.
Arenaviruses (Developments in Biochemistry) by Colin R. Howard, Howard