By Susan L. McElroy, Paul E. Keck Jr., Robert M. Post
Several antiepileptic medications (AEDs) now have regulatory symptoms for treating bipolar affliction. there's becoming proof that AEDs mostly have a number of helpful psychotropic results. Antiepileptic medicines to regard Psychiatric problems is the 1st entire, clinically orientated reference at the use of AEDs to regard numerous psychiatric stipulations equivalent to temper, psychotic, anxiousness, substance use, consuming, and character problems. Written by way of the best scientific specialists, the booklet is geared up by way of psychiatric affliction for less complicated details accumulating, allowing physicians to exploit the textual content as a standalone reference.
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Extra info for Antiepileptic Drugs to Treat Psychiatric Disorders
PO MHD and oxcarbazepine dose-dependently ; 10 mechanical hyperalgesia in guinea pigs (MHD is slightly less potent than parent compound). IP oxcarbazepine dose-dependently ; 15 mechanical and cold allodynia in rats. IP topiramate ; mechanical allodynia in rats. 21 IP topiramate ; mechanical hyperalgesia and cold 9 allodynia but has no effect on mechanical allodynia in rats after chronic constriction injury (sciatic nerve). IP topiramate ; cold allodynia and thermal hyperalgesia but has no effect on mechanical allodynia in rats after crush injury (sciatic nerve).
MMW Munch Med Wochenschr 1912; 59:1907–1909. 3. Kale R, Perucca E. Revisiting phenobarbital for epilepsy. BMJ 2004 Nov 20; 329 (7476):1199–1200. 4. Spina E, Perugi G. Antiepileptic drugs: indications other than epilepsy. Epileptic Disord 2004; 6(2):57–75. 5. Fisher RS, van Emde Boas W, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005; 46(4):470–472. 6. Merritt HH, Putnam TJ.
Changing from one AED to another can be a fairly complicated procedure. It is done gradually over weeks to months. 3d] [29/4/08/11:27:19] [17–32] 26 Tomson Individualization of Dosage AED dosage needs to be tailored to the needs of the individual patient. The general strategy is to use the lowest effective dosage aiming at complete seizure control without embarrassing or intolerable adverse effects. There is a marked interindividual variability in the dosage that provides the optimal balance between efficacy and tolerability, and this has to be achieved in each patient in a systematic manner.
Antiepileptic Drugs to Treat Psychiatric Disorders by Susan L. McElroy, Paul E. Keck Jr., Robert M. Post